Endocrine Abstracts

Objectives: Alemtuzumab, a monoclonal antibody against CD52, is used in the treatment of multiple sclerosis. A side effect to the treatment is development of autoimmune thyroid disease. The aim was to evaluate the rate, type and course of thyroid disease in Danish patients with multiple sclerosis (MS) previously treated with Alemtuzumab.Methods: The study was a retrospective cohort study of patients treated with first series of alemtuzumab for multiple s...

Objective: Evaluate the influence of altered cortisol binding globulin (CBG) concentration on total cortisol and calculated free cortisol (CFC) during the 250 μg ACTH test.Methods: We included 100 unmedicated healthy individuals (HI) (50M:50F), 13 women taking oral contraception (OC), and 5 men with nefrotic syndrome (NS, prior to glucocorticoid treatment; hypoalbuminaemia <9 g/l; proteinuria >1.6 g/24 h). An ACTH-test was performed between ...

Introduction: Thyroid autoimmunity has been associated with pregnancy loss. A possible mechanism is an overactive maternal immune system leading to rejection of the fetal allograft. In women with recurrent pregnancy losses (RPL), we investigated the association of thyroid peroxidase antibodies (TPOAbs) with number of losses and outcome of first pregnancy after referral.Methods: Prospective study of women with RPL (≥3) followed at the RPL Unit, Cope...

Objectives: Iodine intake affects the risk of thyroid disorders. This study aimed to calculate the overall incidence of thyroid dysfunctions and structural abnormalities in the Faroe Islands and to describe the relation to sex and age.Methods: We performed a nationwide, register-based study covering all 54,000 inhabitants of the Faroe Islands between 2006 and 2018. Cases were identified and classified by thyroid dysfunction using redeemed prescriptions o...

A GH peak of 3 μg/l during the insulin tolerance test (ITT) is considered the gold standard for identifying adults with severe GH deficiency. Alternative stimuli such as arginine (AST) and glucagon (GST) are also employed but produce lower GH peaks than the ITT in normal subjects. Despite this, 3 μg/l is used as the diagnostic threshold for these tests, raising the possibility that severe GH deficiency is being diagnosed inappropriately.We stud...

Head and neck paragangliomas (HNPGLs) are a type of neuroendocrine tumour. They arise from the sympathetic ganglia and can be either sporadic or due to hereditary syndromes (up to 40%). Most HNPGLs do not produce significant amounts of catecholamines1. Often, HNPGLs are detected in late stages due to compression or infiltration of cranial structures1. We report a case of a paraganglioma of the basis cranii due to somatic variants of SDHB (succinate dehydr...

Background: Acromegaly is associated with increased morbidity and mortality if left untreated. The therapeutic options include surgery, medical treatment, and radiotherapy. Guidelines regarding treatment algorithms and follow-up vary considerably.Aim: To evaluate consensus on the treatment and follow-up of acromegaly in the Scandinavian countries.Methods: To map the landscape of acromegaly management in the Scandinavian countries, ...